During development, disease or in response to changes in local environmental and/or nutrient supply, cellular metabolism is substantially remodeled. Reduced mitochondrial Ca2+ uptake was recently reported to induce metabolic remodeling, which through stimulating alterations in the epigenome causes changes in gene expression associated with fibroblast to myofibroblast differentiation.
Keywords: Calcium signalling; Epigenome; Fibrosis; Metabolic remodelling; Mitochondrial calcium; Myofibroblasts.
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