Vitiligo - New Treatment Approach

Veronika A Konstantinova; Olga Yu Olisova; Victor V Gladko; Ekaterina P Burova

doi:10.2147/CCID.S229175

Vitiligo - New Treatment Approach

Clin Cosmet Investig Dermatol. 2019 Dec 18:12:911-917. doi: 10.2147/CCID.S229175. eCollection 2019.

Authors

Veronika A Konstantinova¹, Olga Yu Olisova², Victor V Gladko³, Ekaterina P Burova^{2

3

4}

Affiliations

¹ Dermatology and Cosmetology Department Dao Clinic, Leninskiy Prospekt, Moscow 119119, Russia.
² Rakhmanov Department of Dermatology and Venereal Diseases, I.M.Sechenov First Moscow State Medical University of the Russian Federation, Moscow 119435, Russia.
³ Department of Dermatology, Venereology and Cosmetology Medical Institute of Continuing Medical Education, Moscow State University of Food Production, Moscow 125080, Russia.
⁴ Dermatology Department Bedford Hospital NHS Trust, South Wing, Bedford MK42 9DJ, UK.

Abstract

Introduction: Vitiligo is one of the most common hypomelanoses. Current treatments include ultraviolet, topical corticosteroids, calcineurin inhibitors. Orally administered vitamins, acting as anti-oxidants and in combination with ultraviolet light have also demonstrated skin re-pigmentation. In our pilot study of seven patients, we injected skin affected with vitiligo intra-dermally with a complex of vitamins and minerals and assessed the outcome.

Aim: The aim of this study was to evaluate a novel treatment modality for vitiligo.

Methods: We present a pilot study of seven patients; each having been diagnosed with generalized progressive vitiligo. In all cases, multiple therapies had been previously attempted. All patients were subjected to intradermal injections of biorevitalizant NCTF 135 (3 mls) in the hypo-pigmented areas of skin, once a week for 5 weeks. A 30Gx13 mm needle was used for the 0.025 mls intradermal injections to create micro-papules with a 1 cm distance between the injection sites. The results were assessed at 2 weeks and 5 weeks and were considered successful if partial or complete repigmentation was achieved.

Results: Partial or complete skin re-pigmentation post-treatment was observed in vitiligo macules of all patients (100%). No significant side effects, or exacerbation of vitiligo were observed during or after treatment with NCTF 135 in the following 6 months (five patients) and 12 months (two patients).

Discussion: Increasing the armamentarium of new treatments of vitiligo is important. Previous studies showed the effectiveness of oral and intramuscularly injected multivitamins in the treatment of vitiligo, explaining the results by the antioxidative qualities of the above. Our study demonstrated that intradermal mesotherapy injections of NCTF135, rich with vitamins and other antioxidants are well tolerated and effective in achieving significant re-pigmentation of de-pigmented skin in all patients studied, including five who had been resistant to previous standard therapies.

Keywords: antioxidants; mesotherapy; vitamins and minerals.