Prenylated p-Terphenyls from a Mangrove Endophytic Fungus, Aspergillus candidus LDJ-5

J Nat Prod. 2020 Jan 24;83(1):8-13. doi: 10.1021/acs.jnatprod.9b00004. Epub 2020 Jan 6.

Abstract

Nine previously undescribed prenylated p-terphenyls, prenylterphenyllins F-J (1, 2, 4-6) and prenylcandidusins D-G (3, 7-9), were isolated from an endophytic fungus, Aspergillus candidus LDJ-5. Their structures were determined from NMR and MS data. Differing from previously reported p-terphenyls, compound 3 represents a rare 6,5,6,6-fused ring system. Compounds 4-6 are antimicrobial, and compounds 1, 4, 6, and 9 are cytotoxic.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / pharmacology
  • Aspergillus / chemistry*
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Terphenyl Compounds / chemistry*
  • Terphenyl Compounds / pharmacology

Substances

  • Anti-Bacterial Agents
  • Terphenyl Compounds

Supplementary concepts

  • Aspergillus candidus