[Mechanism of action and adverse effects of monoclonal antibodies]

Theodora Bejan-Angoulvant; Joachim Alexandre

doi:10.1051/medsci/2019208

[Mechanism of action and adverse effects of monoclonal antibodies]

Med Sci (Paris). 2019 Dec;35(12):1114-1120. doi: 10.1051/medsci/2019208. Epub 2020 Jan 6.

[Article in French]

Authors

Theodora Bejan-Angoulvant¹, Joachim Alexandre²

Affiliations

¹ Service de Pharmacologie médicale, CHRU de Tours ; EA 7501, GICC, équipe PATCH, Université de Tours, 37000 Tours, France - LabEx MabImprove,.
² Service de Pharmacologie, CHU Caen ; EA4650, Normandie Université, Caen, 14000, France.

PMID: 31903925
DOI: 10.1051/medsci/2019208

Abstract

Monoclonal antibodies are therapeutic monoclonal Ig that act by highly specific binding to their target antigen and by interacting with the immune system. Their side effects are mainly related to their mechanism of action. The most frequent adverse effects are infusion reactions. Post-marketing surveillance is essential for identifying adverse reactions and improving knowledge of their mechanism of action.

Publication types

Review

MeSH terms

Animals
Antibodies, Monoclonal / adverse effects*
Antibodies, Monoclonal / immunology
Antibodies, Monoclonal / therapeutic use
Drug-Related Side Effects and Adverse Reactions* / epidemiology
Drug-Related Side Effects and Adverse Reactions* / etiology
Drug-Related Side Effects and Adverse Reactions* / immunology
Humans
Immune System / drug effects*
Immune System / immunology
Immune System / metabolism
Product Surveillance, Postmarketing
Signal Transduction / drug effects
Signal Transduction / immunology

Substances

Antibodies, Monoclonal