This article presents a high energy efficiency, high-integrated, and low-power on-off keying transceiver for a 2.4 GHz industrial scientific medical band. The proposed receiver includes an input matching network, a low-noise amplifier, a novel single-to-differential envelope detector, a level shifter, cascaded baseband amplifiers, and a hysteresis comparator. The proposed transmitter includes a bias-stimulating circuit, a current-reused self-mixing voltage controlled oscillator, and a quadruple-transconductance power amplifier. Numerous proposed techniques implemented in the mentioned circuits improve the energy per bit and power efficiency. Therefore, the proposed receiver for short-distanced propagation can achieve a sensitivity of -46 dBm with a carrier frequency of 2.45 GHz and a high data rate of 2 Mbps. The proposed transmitter achieves an output power of -17 dBm with a high data rate of 20 Mbps. This work is fabricated in a TSMC 0.18 μm CMOS process and consumes 160 μW and 0.6 mW in the receiver and transmitter, respectively, from a 1.2 V supply voltage. The energy per bit of 80 pJ/bit in the receiver part and the figure of merit of 9 in the transmitter part are better than those of existing state-of-the-art transceivers.