Cycloartane triterpenoids from Pseudolarix amabilis and their antiviral activity

Xiao-Tong Zhao; Mei-Hua Yu; Shi-Yun Su; Xun-Long Shi; Chun Lei; Ai-Jun Hou

doi:10.1016/j.phytochem.2019.112229

Cycloartane triterpenoids from Pseudolarix amabilis and their antiviral activity

Phytochemistry. 2020 Mar:171:112229. doi: 10.1016/j.phytochem.2019.112229. Epub 2020 Jan 1.

Authors

Xiao-Tong Zhao¹, Mei-Hua Yu¹, Shi-Yun Su¹, Xun-Long Shi¹, Chun Lei², Ai-Jun Hou³

Affiliations

¹ School of Pharmacy, Fudan University, Shanghai, 201203, China.
² School of Pharmacy, Fudan University, Shanghai, 201203, China. Electronic address: chunlei@fudan.edu.cn.
³ School of Pharmacy, Fudan University, Shanghai, 201203, China. Electronic address: ajhou@shmu.edu.cn.

PMID: 31901474
DOI: 10.1016/j.phytochem.2019.112229

Abstract

Seven undescribed cycloartane triterpenoids, pseudolarnoids A-G, together with ten known ones, were isolated from the seeds of Pseudolarix amabilis (J. Nelson) Rehder. Their structures were elucidated on the basis of spectroscopic analysis, X-ray crystallography, and ECD data. Pseudolarnoids A-C are cycloartane triterpenoids with a unique 16S, 23R-spirolactone moiety. Pseudolarnoids F, G, and pseudolarolide C demonstrated potent antiviral effects on HSV-1 in vitro.

Keywords: Antiviral activity; Cycloartane triterpenoids; Pinaceae; Pseudolarix amabilis (J. Nelson) Rehder; Pseudolarnoids A−G.

MeSH terms

Antiviral Agents / chemistry
Antiviral Agents / isolation & purification
Antiviral Agents / pharmacology*
Crystallography, X-Ray
Herpesvirus 1, Human / drug effects*
Influenza A Virus, H3N2 Subtype / drug effects*
Microbial Sensitivity Tests
Models, Molecular
Molecular Conformation
Phytochemicals / chemistry
Phytochemicals / isolation & purification
Phytochemicals / pharmacology*
Pinaceae / chemistry
Triterpenes / chemistry
Triterpenes / isolation & purification
Triterpenes / pharmacology*

Substances

Antiviral Agents
Phytochemicals
Triterpenes
cycloartane