The Inhibition of the Histone Methyltransferase EZH2 by DZNEP or SiRNA Demonstrates Its Involvement in MGMT, TRA2A, RPS6KA2, and U2AF1 Gene Regulation in Prostate Cancer

OMICS. 2020 Feb;24(2):116-118. doi: 10.1089/omi.2019.0162. Epub 2019 Dec 31.

Authors

Driss El Ouardi^{1

2}, Mouhamed Idrissou^{1

2}, Anna Sanchez^{1

2}, Frédérique Penault-Llorca^{2

3}, Yves-Jean Bignon^{1

2}, Laurent Guy^{2

4}, Dominique Bernard-Gallon^{1

2}

Affiliations

¹ Department of Oncogenetics, Centre Jean Perrin, CBRV, Clermont-Ferrand, France.
² INSERM-U1240-Molecular Imaging and Theranostic Strategies (IMOST), Clermont-Ferrand, France.
³ Department of Biopathology, Centre Jean Perrin, Clermont-Ferrand, France.
⁴ Department of Urology, Gabriel Montpied Hospital, Clermont-Ferrand, France.

PMID: 31895624
DOI: 10.1089/omi.2019.0162

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

DNA Modification Methylases / genetics*
DNA Modification Methylases / metabolism
DNA Repair Enzymes / genetics*
DNA Repair Enzymes / metabolism
Enhancer of Zeste Homolog 2 Protein / antagonists & inhibitors*
Enhancer of Zeste Homolog 2 Protein / genetics*
Enhancer of Zeste Homolog 2 Protein / metabolism
Gene Expression Regulation, Neoplastic*
Humans
Male
Prostatic Neoplasms / genetics*
Prostatic Neoplasms / metabolism
RNA, Small Interfering / genetics*
Ribosomal Protein S6 Kinases, 90-kDa / genetics*
Ribosomal Protein S6 Kinases, 90-kDa / metabolism
Splicing Factor U2AF / genetics*
Splicing Factor U2AF / metabolism
Tumor Suppressor Proteins / genetics*
Tumor Suppressor Proteins / metabolism

Substances

RNA, Small Interfering
Splicing Factor U2AF
Tumor Suppressor Proteins
U2AF1 protein, human
DNA Modification Methylases
EZH2 protein, human
Enhancer of Zeste Homolog 2 Protein
MGMT protein, human
Ribosomal Protein S6 Kinases, 90-kDa
ribosomal protein S6 kinase, 90kDa, polypeptide 3
DNA Repair Enzymes