Data of epigenomic profiling of histone marks and CTCF binding sites in bovine rumen epithelial primary cells before and after butyrate treatment

Xiaolong Kang; Shuli Liu; Lingzhao Fang; Shudai Lin; Mei Liu; Ransom L Baldwin; George E Liu; Cong-Jun Li

doi:10.1016/j.dib.2019.104983

Data of epigenomic profiling of histone marks and CTCF binding sites in bovine rumen epithelial primary cells before and after butyrate treatment

Data Brief. 2019 Dec 12:28:104983. doi: 10.1016/j.dib.2019.104983. eCollection 2020 Feb.

Authors

Xiaolong Kang^{1

2}, Shuli Liu^{1

3}, Lingzhao Fang⁴, Shudai Lin⁵, Mei Liu⁶, Ransom L Baldwin¹, George E Liu¹, Cong-Jun Li¹

Affiliations

¹ Animal Genomics and Improvement Laboratory, BARC, Agricultural Research Service, USDA, Beltsville, MD 20705, USA.
² College of Agriculture, Ningxia University, Yinchuan 750021, China.
³ College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
⁴ University of Edinburgh, Edinburgh EH4 2XU, United Kingdom.
⁵ College of Animal Science of South China Agricultural University, Guangzhou 510642, China.
⁶ College of Animal Science and Technology, Northwest A&F University, Shaanxi Key Laboratory of Agricultural Molecular Biology, Yangling 712100, China.

Abstract

Discovering the regulatory elements of genomes in livestock is essential for our understanding of livestock's basic biology and genomic improvement programs. Previous studies showed butyrate mediates epigenetic modifications of bovine cells. To explore the bovine functional genomic elements and the vital roles of butyrate on the epigenetic modifications of bovine genomic activities, we generated and deposited the genome-wide datasets of transcript factor binding sites of CTCF (CCCTC-binding factor, insulator binding protein), histone methylation (H3H27me3, H3K4me1, H3K4me3) and histone acetylation (H3K27ac) from bovine rumen epithelial primary cells (REPC) before and after butyrate treatment (doi: 10.1186/s12915-019-0687-8 [1]). In this dataset, we provide detailed information on experiment design, data generation, data quality assessment and guideline for data re-use. Our data will be a valuable resource for systematic annotation of regulatory elements in cattle and the functionally biological role of butyrate in the epigenetic modifications in bovine, as well as for the nutritional regulation and metabolism study of farm animal and human.

Keywords: Bovine rumen; Butyrate; CTCF; Histone marks.