Comparison of 18FBPA uptake with 18FDG uptake in cancer patients

Hiroshi Igaki; Satoshi Nakamura; Hiroaki Kurihara; Yoshihisa Abe; Shie Nishioka; Ryo Fujii; Masaru Nakamura; Yuko Nakayama; Takahiro Morita; Hiroyuki Okamoto; Yoshio Imahori; Jun Itami

doi:10.1016/j.apradiso.2019.109019

Comparison of ¹⁸FBPA uptake with ¹⁸FDG uptake in cancer patients

Appl Radiat Isot. 2020 Mar:157:109019. doi: 10.1016/j.apradiso.2019.109019. Epub 2019 Dec 7.

Authors

Affiliations

¹ Department of Radiation Oncology, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan; Division of Research and Development for Boron Neutron Capture Therapy, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. Electronic address: hirigaki@ncc.go.jp.
² Division of Research and Development for Boron Neutron Capture Therapy, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan; Department of Medical Physics, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. Electronic address: satonaka@ncc.go.jp.
³ Department of Diagnostic Radiology, Kangawa Cancer Center Hospital, 2-3-2, Nakao, Asahi-ku, Yokohama, 241-8515, Japan; Department of Diagnostic Radiology, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. Electronic address: h-kurihara@kcch.jp.
⁴ Division of Research and Development for Boron Neutron Capture Therapy, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan; Department of Radiological Technology, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. Electronic address: yoabe@ncc.go.jp.
⁵ Department of Medical Physics, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. Electronic address: snishiok@ncc.go.jp.
⁶ Cancer Intelligence Care Systems, Inc. 17th Floor of TOC Ariake West Tower, 3-5-7, Ariake, Koto-ku, Tokyo, 135-0063, Japan. Electronic address: fujii@cics.jp.
⁷ Cancer Intelligence Care Systems, Inc. 17th Floor of TOC Ariake West Tower, 3-5-7, Ariake, Koto-ku, Tokyo, 135-0063, Japan. Electronic address: nakamura@cics.jp.
⁸ Department of Radiation Oncology, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. Electronic address: yukonak4@ncc.go.jp.
⁹ Department of Diagnostic Radiology, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. Electronic address: tamorita@ncc.go.jp.
¹⁰ Department of Medical Physics, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. Electronic address: hiokamot@ncc.go.jp.
¹¹ Cancer Intelligence Care Systems, Inc. 17th Floor of TOC Ariake West Tower, 3-5-7, Ariake, Koto-ku, Tokyo, 135-0063, Japan. Electronic address: imahori@cics.jp.
¹² Department of Radiation Oncology, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan; Division of Research and Development for Boron Neutron Capture Therapy, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. Electronic address: jitami@ncc.go.jp.

PMID: 31889678
DOI: 10.1016/j.apradiso.2019.109019

Abstract

For the patients who underwent ¹⁸fluorinated para-boronophenylalanine (¹⁸FBPA) positron emission tomography (PET) and ¹⁸fluorodeoxyglucose (¹⁸FDG) PET within a period of 2 weeks, maximum standardized uptake value (SUVmax), tumor-to-normal tissue ratio (TNR), and tumor-to-blood ratio (TBR) for ¹⁸FBPA were compared with SUVmax for ¹⁸FDG. A total of 30 patients were selected for comparison. SUVmax for ¹⁸FBPA was correlated the best with SUVmax for ¹⁸FDG. Subsequently, the SUVmax correlation between ¹⁸FBPA and ¹⁸FDG were verified among 82 patients. The correlation factor was 0.4825.

Keywords: (18)FBPA; (18)FDG; Boron neutron capture therapy; Positron emission tomography.

Publication types

Comparative Study

MeSH terms

Adolescent
Adult
Aged
Aged, 80 and over
Boron Compounds / metabolism*
Child
Female
Fluorodeoxyglucose F18 / metabolism*
Humans
Male
Melanoma / metabolism*
Melanoma / pathology
Middle Aged
Phenylalanine / analogs & derivatives*
Phenylalanine / metabolism
Positron-Emission Tomography / methods
Young Adult

Substances

Boron Compounds
Fluorodeoxyglucose F18
Phenylalanine
4-boronophenylalanine