MMP-2, -3 and TIMP-2, -3 polymorphisms in colorectal cancer in a Chinese Han population: A case-control study

Abstract

Purpose: The goal of this study is to evaluate the association between MMP-2, 3, TIMP-2, 3 polymorphisms and risk of colorectal cancer (CRC) in a Chinese Han population.

Methods: Eight single nucleotide polymorphisms (SNP) were genotyped in 505 CRC patients and 510 controls. The association between candidate SNPs and risk of CRC were evaluated using odds ratio (OR), 95% confidence interval (95% CI).

Results: The minor allele frequency of rs1053605 in cases was significantly lower than controls (p = 0.005). The CT genotype frequency of rs1053605 in cases was significantly lower than those in controls, while the frequencies of rs4789936-CT and rs715572-AG genotype of in cases were significantly higher than those in controls (p < 0.05). Genetic model analysis showed that rs522616 was associated with decreased risk of CRC under recessive model (p = 0.041); rs1053605 was correlated with decreased risk of CRC under dominant (p = 0.012) and additive (p = 0.009) models; rs4789936 also has association with decreased risk of CRC under recessive model (p = 0.021); while rs715572 was associated with increased risk of CRC under dominant (p = 0.007) and additive (p = 0.011) models.

Conclusion: Our results shed new light on association between MMP and TIMP polymorphisms and CRC risk.

Keywords: Case-control study; Colorectal cancer (CRC); Matrix metalloproteinase (MMP); Single nucleotide polymorphisms (SNP); Tissue inhibitors of metalloproteinases (TIMP).