Association between lncRNA H19 polymorphisms and cancer susceptibility based on a meta-analysis from 25 studies

Chunhui Liu; Lusi Chen; Zonghao You; Yuqing Wu; Can Wang; Guangyuan Zhang; Bin Xu; Ming Chen

doi:10.1016/j.gene.2019.144317

Association between lncRNA H19 polymorphisms and cancer susceptibility based on a meta-analysis from 25 studies

Gene. 2020 Mar 1:729:144317. doi: 10.1016/j.gene.2019.144317. Epub 2019 Dec 26.

Authors

Chunhui Liu¹, Lusi Chen², Zonghao You¹, Yuqing Wu¹, Can Wang¹, Guangyuan Zhang¹, Bin Xu¹, Ming Chen³

Affiliations

¹ Department of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, China; Surgical Research Center, Institute of Urology, Southeast University Medical School, Nanjing, China.
² Department of Epidemiology and Health Statistics, Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, China.
³ Department of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, China; Surgical Research Center, Institute of Urology, Southeast University Medical School, Nanjing, China. Electronic address: mingchenseu@126.com.

PMID: 31884107
DOI: 10.1016/j.gene.2019.144317

Abstract

Background: Long non-coding RNA H19 polymorphisms were reported to be related to cancer susceptibility. However, the results from individual studies have been controversial or inconsistent. To clarify the associations between H19 single nucleotide polymorphisms (rs2107425, rs217727, rs2735971, rs2839698, rs3024270, and rs3741219) and the cancer susceptibility more accurately.

Methods: Relevant publications were searched from PubMed and EMBASE up to May 31, 2019, for studies in English only. The reference lists of the retrieved studies were also investigated. Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated to find out the relationship between the H19 polymorphisms and cancer susceptibility. All of the data were analyzed using Stata 12.0.

Results: The results showed that rs2107425 polymorphisms was associated with an increasing cancer susceptibility in Asian (T vs C: OR 1.13, 95% CI 1.01-1.28; TT + CT vs CC: OR 1.21, 95% CI 1.03-1.44; CT vs CC: OR 1.21, 95% CI 1.01-1.44) and decreasing risk in Caucasian (T vs C: OR 0.90, 95% CI 0.84-0.97; TT + CT vs CC: OR 0.84, 95% CI 0.75-0.94; CT vs CC: OR 0.82, 95% CI 0.72-0.94). And rs217727 polymorphism was associated with an increasing cancer susceptibility in the Asian (A vs G: OR 1.09, 95% CI 1.02-1.17; AA + GA vs GG: OR 1.12, 95% CI 1.01-1.21; AA vs GG: OR 1.18, 95% CI 1.02-1.36). Additionally, rs2839698 polymorphism was associated with an increasing risk overall (A vs G: OR 1.18, 95% CI 1.06-1.31), in breast cancer (A vs G: OR 1.67, 95% CI 1.14-2.45; AA + AG vs GG: OR 1.98, 95% CI 1.20-3.25; AG vs GG: OR 1.89, 95% CI 1.16-3.07), in Asian (A vs G: OR 1.09, 95% CI 1.03-1.14; AA + AG vs GG: OR 1.11, 95% CI 1.04-1.21; AA vs AG + GG: OR 1.12, 95% CI 1.01-1.25; AA vs GG: OR 1.15, 95% CI 1.01-1.49; AG vs GG: OR 1.09, 95% CI 1.02-1.17), and in Caucasian (AA vs AG + GG: OR 1.81, 95% CI 1.25-2.61).

Conclusion: H19 rs2107425, rs217727 and rs2839698 were associated with an increasing cancer susceptibility in Asian. Rs2107425 was associated with a decreasing risk and rs2839698 was associated with an increasing risk in Caucasian. No significant association was found in H19 rs2735971, rs3024270 and rs3741219 polymorphisms and cancer susceptibility.

Keywords: Cancer; H19; Meta-analysis; Polymorphism; Susceptibility.

Publication types

Meta-Analysis
Review

MeSH terms

Asian People / genetics
Case-Control Studies
Disease Susceptibility
Female
Genetic Association Studies
Genetic Predisposition to Disease / genetics
Humans
Male
Neoplasms / genetics*
Odds Ratio
Polymorphism, Genetic / genetics
RNA, Long Noncoding / genetics*
RNA, Long Noncoding / metabolism
Risk Factors
White People / genetics

Substances

H19 long non-coding RNA
RNA, Long Noncoding