Objective: Gingival squamous cell carcinoma (GSCC) is one of the most common malignancies. Endogenous ribosomal protein L29 (RPL29) has been previously proven to be up-regulated in cancer tissues. However, RPL29 expression in GSCC has not been described.
Methods: The knockdown of RPL29 gene in GSCC cells was carried out to study the influence of RPL29 silencing on GSCC cells.
Results: We investigated the influence on cell proliferation, invasion, and related biomarkers, which led us to confirm that all were repressed by the knockdown of RPL29.
Conclusion: The role of RPL29 should lead to a better understanding of the development and progression of human GSCC.
Keywords: Gingival squamous cell carcinoma (GSCC); RPL29; SCCs; cell invasion; cell proliferation.
© 2019 by the Association of Clinical Scientists, Inc.