Clerodane diterpenoids with potential anti-inflammatory activity from the leaves and twigs of Callicarpa cathayana

Abstract

Phytochemical investigation of the leaves and twigs of Callicarpa cathayana led to the isolation of six new clerodane diterpenoids, cathayanalactones A-F (1-6), together with seven analogues (7-13). Their structures were established by extensive NMR analyses together with experimental and calculated ECD spectra analyses. Compounds 1, 2, 3, 7 and 11 showed inhibitory activities on lipopolysaccharide-induced nitric oxide production in RAW264.7 cells.

Keywords: Anti-inflammatory activity; Callicarpa cathayana; Clerodane diterpenoids; Nitric oxide.