Four new corynanthe-type alkaloids from the roots of Alstonia scholaris

Chin J Nat Med. 2019 Dec;17(12):918-923. doi: 10.1016/S1875-5364(19)30113-X.

Abstract

Four new corynanthe-type alkaloids, meloslines C-F (1-4), together with four known ones (5-8) were isolated from the roots of Alstonia scholaris. Their structures including absolute configurations were elucidated by extensive spectroscopic analysis and electronic circular dichroism (ECD) calculation. Compounds 1 and 2 exhibited potent vasorelaxant activity on endothelium-intact renal arteries precontracted with KCl.

Keywords: Alstonia scholaris; Apocynaceae; Corynanthe-type alkaloids; Vasorelaxant activity.

MeSH terms

  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology*
  • Alstonia / chemistry*
  • Animals
  • China
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Pausinystalia / chemistry*
  • Plant Roots / chemistry*
  • Rats, Sprague-Dawley
  • Renal Artery / drug effects
  • Vasodilator Agents / isolation & purification
  • Vasodilator Agents / pharmacology*

Substances

  • Alkaloids
  • Vasodilator Agents