Evolving nanoformulation strategies for diagnosis and clinical interventions for Parkinson's disease

Sunita Chawla; Dnyaneshwar Kalyane; Vishakha Tambe; Pran Kishore Deb; Kiran Kalia; Rakesh K Tekade

doi:10.1016/j.drudis.2019.12.005

Evolving nanoformulation strategies for diagnosis and clinical interventions for Parkinson's disease

Drug Discov Today. 2020 Feb;25(2):392-405. doi: 10.1016/j.drudis.2019.12.005. Epub 2019 Dec 23.

Authors

Sunita Chawla¹, Dnyaneshwar Kalyane¹, Vishakha Tambe¹, Pran Kishore Deb², Kiran Kalia¹, Rakesh K Tekade³

Affiliations

¹ National Institute of Pharmaceutical Education and Research (NIPER) - Ahmedabad, An Institute of National Importance, Government of India, Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Palaj, Opposite Air Force Station, Gandhinagar 382355, Gujarat, India.
² Faculty of Pharmacy, Philadelphia University, P.O. Box 1, 19392, Jordan. Electronic address: prankishore1@gmail.com.
³ National Institute of Pharmaceutical Education and Research (NIPER) - Ahmedabad, An Institute of National Importance, Government of India, Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Palaj, Opposite Air Force Station, Gandhinagar 382355, Gujarat, India; Department of Materials Engineering, Indian Institute of Technology-Jammu, Jagti, Tahsil Nagrota, Jammu 181 221, J&K, India. Electronic address: rakeshtekade@gmail.com.

PMID: 31877354
DOI: 10.1016/j.drudis.2019.12.005

Abstract

Parkinson's disease (PD) is the most common neurodegenerative disease and is associated with a loss of dopaminergic neurons in the substantia nigra. Currently available treatments provide only symptomatic relief and there is no proper diagnosis tool to detect early stages of PD. Recently, nanomedicines and nanoformulation strategies have been widely adopted for the diagnosis and treatment of PD owing to their ability to improve treatment efficacy and provide unique diagnostic functions. Furthermore, advances in nanomedicine limit the potential side effects associated with conventional therapy and provide targeted drug delivery. The objective of this review is to discuss nanoformulation strategies used for the treatment as well as the diagnosis of PD.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Humans
Nanoparticles / therapeutic use*
Nanotechnology
Parkinson Disease / diagnosis*
Parkinson Disease / drug therapy*