Abstract
We have analyzed T cell receptor repertoires in a unique set of thymus samples from a pair of monozygotic twins. While genetics affect the V(D)J rearrangement and generation of junctional sequences, the thymic selections seem largely stochastic and import no detectable inheritable effect at clonal level.
Keywords:
CDR3; TCR repertoire; genetics; thymic selection; twins.
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Complementarity Determining Regions / genetics*
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Gene Expression
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High-Throughput Nucleotide Sequencing
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Humans
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Receptors, Antigen, T-Cell, alpha-beta / classification
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Receptors, Antigen, T-Cell, alpha-beta / genetics*
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Receptors, Antigen, T-Cell, alpha-beta / immunology
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T-Lymphocyte Subsets / classification
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T-Lymphocyte Subsets / cytology
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T-Lymphocyte Subsets / immunology
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Thymus Gland / cytology
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Thymus Gland / immunology
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Twins, Monozygotic*
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V(D)J Recombination / immunology*
Substances
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Complementarity Determining Regions
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Receptors, Antigen, T-Cell, alpha-beta