Data presenting the synthesis of three novel stimuli responsive hyperbranched polymers synthesised via RAFT polymerisation and the bio conjugation of folic acid

Chester Blackburn; Hongyun Tai; Martina Salerno; Xi Wang; Chandra Senan; Ian Ratcliffe; Edgar Hartsuiker; Wenxin Wang

doi:10.1016/j.dib.2019.104861

Data presenting the synthesis of three novel stimuli responsive hyperbranched polymers synthesised via RAFT polymerisation and the bio conjugation of folic acid

Data Brief. 2019 Nov 21:28:104861. doi: 10.1016/j.dib.2019.104861. eCollection 2020 Feb.

Authors

Chester Blackburn¹, Hongyun Tai¹, Martina Salerno², Xi Wang³, Chandra Senan⁴, Ian Ratcliffe⁴, Edgar Hartsuiker², Wenxin Wang³

Affiliations

¹ School of Natural Sciences, Bangor University, Deiniol Road, Bangor, Gwynedd, LL57 2UW, UK.
² NWCR Institute, School of Medical Sciences, Bangor University, Deiniol Road, Bangor, Gwynedd, LL57 2UW, UK.
³ Charles Institute of Dermatology, School of Medicine, University College Dublin, Dublin 4, Ireland.
⁴ Centre for Water Soluble Polymers, Wrexham Glyndwr University, Wrexham, LL11 2AW, Wales, UK.

Abstract

The data presented in this manuscript presents the characterisation spectra of three hyperbranched polymers as discussed in the paper "Folic Acid and Rhodamine Labelled pH Responsive Hyperbranched Polymers: synthesis, characterisation and cell uptake studies" [1]. Characterisation of polymers was performed via ¹H Nuclear Magnetic Resonance (¹H NMR) and Size Exclusion Chromatography (SEC). pH responsive characteristics were observed via Dynamic Light Scattering (DLS). The data for characterisation of folate conjugated hyperbranched polymer is presented as ¹H NMR, Ultra Violet Visible (UV-VIS) spectra and DLS measurements. Further data is presented detailing the experiments for the synthesis of monomers 2-propyl acrylic acid (PAA) and disulfide diacrylate (DSDA), with the full synthesis of folic acid-poly (ethylene glycol) (PEG) linker, rhodamine B ethylenediamine linker and bioconjugation reactions also detailed.

Keywords: Hyperbranched polymers; RAFT polymerisation; Targeted delivery; pH responsive.