Interfacial bonding in formulated bilayer tablets

Shao-Yu Chang; Changquan Calvin Sun

doi:10.1016/j.ejpb.2019.12.009

Interfacial bonding in formulated bilayer tablets

Eur J Pharm Biopharm. 2020 Feb:147:69-75. doi: 10.1016/j.ejpb.2019.12.009. Epub 2019 Dec 21.

Authors

Shao-Yu Chang¹, Changquan Calvin Sun²

Affiliations

¹ Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, 9-127B Weaver-Densford Hall, 308 Harvard Street S.E., Minneapolis, MN 55455, USA.
² Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, 9-127B Weaver-Densford Hall, 308 Harvard Street S.E., Minneapolis, MN 55455, USA. Electronic address: sunx0053@umn.edu.

PMID: 31870828
DOI: 10.1016/j.ejpb.2019.12.009

Abstract

To take full advantage of the drug delivery benefits offered by bilayer tablets, the common issue of weak interfacial bonding strength (IBS) with manufacturing must be overcome. This work seeks to characterize the effects of composition in individual layers and compaction pressure on the IBS. Mixtures of MCC and lactose in different ratios with and without HPMC were used where the first layer was compacted with two different pressures (20 and 100 MPa) followed by a second layer compaction pressure of 200 MPa. After identifying the failure mode as either at the interface or within a layer, the complex trends of bilayer tablet IBS as a function of MCC content were explained by considering the interplay between particle bonding strength and bonding area at the interface.

Keywords: Bilayer tablet; Failure mode; HPMC; Interfacial bonding strength; Lactose; Microcrystalline cellulose.

MeSH terms

Cellulose / chemistry
Chemistry, Pharmaceutical / methods*
Drug Compounding / methods
Drug Delivery Systems*
Excipients / chemistry*
Hypromellose Derivatives / chemistry
Lactose / chemistry
Pressure
Tablets
Technology, Pharmaceutical / methods

Substances

Excipients
Tablets
Hypromellose Derivatives
Cellulose
Lactose
microcrystalline cellulose