Soluto-inertial (SI) suspension interactions allow colloidal particles to be driven large distances over sustained periods of time. These interactions involve soluto-inertial "beacons" that establish and maintain solute fluxes over long times by slowly absorbing or emitting solutes in response to changes in the surrounding solution. Suspended particles then migrate in response to solute fluxes via diffusiophoresis (DP). Beacon materials must be chosen to maintain these solute fluxes, with range and duration in mind. Here we present a general strategy to facilitate qualitative design and quantitative prediction of SI interactions for a given beacon-solute pair. Specifically, we look at two classes of SI beacons: those that partition solute and those that associate with solute. We identify the design parameters for these systems to construct a parameter space map, calculate characteristic timescales over which SI fluxes persist, and generate approximate analytical expressions for solute concentration profiles. Further, we use these expressions to predict the DP velocity of colloids interacting with beacons, noting qualitative differences between beacon sources that release solute and beacon sinks that absorb solute. Proof-of-principle experiments of beacon sources and sinks, of partitioning, and associating types highlight the basic findings. More broadly, the conceptual approach outlined here can be adapted to treat SI interactions mediated by other materials such as dissolving solids, gases, evaporating liquids, ion-exchange resins, and others.