Single nucleotide polymorphisms in dopamine receptor D2 are associated with bruxism and its circadian phenotypes in children

Cranio. 2022 Mar;40(2):152-159. doi: 10.1080/08869634.2019.1705629. Epub 2019 Dec 23.

Abstract

Objective: To evaluate the association of bruxism phenotypes with single nucleotide polymorphisms in FKBP5, DRD2, ANKK1, and COMT.Methods: Clinical oral examination was performed to diagnose bruxism phenotypes in 150 children. DNA was collected from saliva. Logistic univariate regression, Chi-square, and Fisher's exact tests were performed (p < 0.05).Results: Bruxism was associated with DRD2 (p = 0.02). Tooth grinding while awake was associated with ANKK1 (p < 0.001), and tooth grinding while asleep was associated with DRD2 in the additive (p = 0.030) and dominant (p = 0.008) model. Tooth clenching while awake was associated with ANKK1 in the additive (p = 0.005) and dominant (p = 0.008) models, whereas tooth clenching while asleep was associated with ANKK1 (p < 0.001) and with COMT in the additive (p = 0.001) and dominant (p = 0.003) models.Discussion: Polymorphisms in DRD2, ANKK1, and COMT are associated with bruxism phenotypes.

Keywords: Bruxism; child; genetics; pediatric dentistry; polymorphism; single nucleotide.

MeSH terms

  • Bruxism* / genetics
  • Catechol O-Methyltransferase
  • Genotype
  • Humans
  • Phenotype
  • Polymorphism, Single Nucleotide*
  • Protein Serine-Threonine Kinases
  • Receptors, Dopamine D2 / genetics*

Substances

  • DRD2 protein, human
  • Receptors, Dopamine D2
  • COMT protein, human
  • Catechol O-Methyltransferase
  • ANKK1 protein, human
  • Protein Serine-Threonine Kinases