Enzyme-responsive fluorescent camptothecin prodrug/polysaccharide supramolecular assembly for targeted cellular imaging and in situ controlled drug release

Chem Commun (Camb). 2020 Jan 23;56(7):1042-1045. doi: 10.1039/c9cc08491f.

Abstract

A novel enzyme-responsive supramolecular polysaccharide assembly composed of disulfide linked adamantane-naphthalimide fluorescent camptothecin prodrug (AdaCPT) and β-CD modified hyaluronic acid (HACD) was constructed, possessing low cellular cytotoxicity and exhibiting targeted cellular imaging and controlled drug release at specific sites while providing a concurrent means for the real-time tracking of drug delivery.

MeSH terms

  • Adamantane / analogs & derivatives
  • Adamantane / chemical synthesis
  • Adamantane / pharmacology
  • Adamantane / toxicity
  • Animals
  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / pharmacology*
  • Antineoplastic Agents / toxicity
  • Camptothecin / chemical synthesis
  • Camptothecin / pharmacology*
  • Camptothecin / toxicity
  • Drug Carriers / chemistry*
  • Drug Liberation
  • Fluorescent Dyes / chemical synthesis
  • Fluorescent Dyes / pharmacology*
  • Fluorescent Dyes / toxicity
  • HCT116 Cells
  • Humans
  • Hyaluronic Acid / chemistry
  • Mice
  • Microscopy, Confocal / methods
  • Microscopy, Fluorescence / methods
  • NIH 3T3 Cells
  • Naphthalimides / chemical synthesis
  • Naphthalimides / pharmacology
  • Naphthalimides / toxicity
  • Prodrugs / chemical synthesis
  • Prodrugs / pharmacology*
  • Prodrugs / toxicity
  • beta-Cyclodextrins / chemistry

Substances

  • Antineoplastic Agents
  • Drug Carriers
  • Fluorescent Dyes
  • Naphthalimides
  • Prodrugs
  • beta-Cyclodextrins
  • Hyaluronic Acid
  • Adamantane
  • Camptothecin