Abstract
A novel enzyme-responsive supramolecular polysaccharide assembly composed of disulfide linked adamantane-naphthalimide fluorescent camptothecin prodrug (AdaCPT) and β-CD modified hyaluronic acid (HACD) was constructed, possessing low cellular cytotoxicity and exhibiting targeted cellular imaging and controlled drug release at specific sites while providing a concurrent means for the real-time tracking of drug delivery.
MeSH terms
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Adamantane / analogs & derivatives
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Adamantane / chemical synthesis
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Adamantane / pharmacology
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Adamantane / toxicity
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Animals
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / pharmacology*
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Antineoplastic Agents / toxicity
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Camptothecin / chemical synthesis
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Camptothecin / pharmacology*
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Camptothecin / toxicity
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Drug Carriers / chemistry*
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Drug Liberation
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Fluorescent Dyes / chemical synthesis
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Fluorescent Dyes / pharmacology*
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Fluorescent Dyes / toxicity
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HCT116 Cells
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Humans
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Hyaluronic Acid / chemistry
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Mice
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Microscopy, Confocal / methods
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Microscopy, Fluorescence / methods
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NIH 3T3 Cells
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Naphthalimides / chemical synthesis
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Naphthalimides / pharmacology
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Naphthalimides / toxicity
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Prodrugs / chemical synthesis
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Prodrugs / pharmacology*
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Prodrugs / toxicity
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beta-Cyclodextrins / chemistry
Substances
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Antineoplastic Agents
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Drug Carriers
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Fluorescent Dyes
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Naphthalimides
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Prodrugs
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beta-Cyclodextrins
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Hyaluronic Acid
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Adamantane
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Camptothecin