Development of Small-Molecule Inhibitors Against Zika Virus Infection

Lili Wang; Ruiying Liang; Yaning Gao; Yanbai Li; Xiaoqian Deng; Rong Xiang; Yina Zhang; Tianlei Ying; Shibo Jiang; Fei Yu

doi:10.3389/fmicb.2019.02725

Development of Small-Molecule Inhibitors Against Zika Virus Infection

Front Microbiol. 2019 Dec 6:10:2725. doi: 10.3389/fmicb.2019.02725. eCollection 2019.

Authors

Lili Wang¹, Ruiying Liang², Yaning Gao³, Yanbai Li², Xiaoqian Deng², Rong Xiang², Yina Zhang², Tianlei Ying⁴, Shibo Jiang⁴, Fei Yu²

Affiliations

¹ Research Center of Chinese Jujube, Hebei Agricultural University, Baoding, China.
² College of Life and Science, Hebei Agricultural University, Baoding, China.
³ Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, China.
⁴ MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.

Abstract

In recent years, the outbreak of infectious disease caused by Zika virus (ZIKV) has posed a major threat to global public health, calling for the development of therapeutics to treat ZIKV disease. Here, we have described the different stages of the ZIKV life cycle and summarized the latest progress in the development of small-molecule inhibitors against ZIKV infection. We have also discussed some general strategies for the discovery of small-molecule ZIKV inhibitors.

Keywords: Zika virus; life cycle; mechanism; small-molecule inhibitor; treatment.

Publication types

Review