Mitochondrially-targeted treatment strategies

Luiz H M Bozi; Juliane C Campos; Vanessa O Zambelli; Nikolas D Ferreira; Julio C B Ferreira

doi:10.1016/j.mam.2019.100836

Mitochondrially-targeted treatment strategies

Mol Aspects Med. 2020 Feb:71:100836. doi: 10.1016/j.mam.2019.100836. Epub 2019 Dec 19.

Authors

Luiz H M Bozi¹, Juliane C Campos¹, Vanessa O Zambelli², Nikolas D Ferreira¹, Julio C B Ferreira³

Affiliations

¹ Institute of Biomedical Sciences, University of Sao Paulo, Brazil.
² Butantan Institute, Sao Paulo, Brazil.
³ Institute of Biomedical Sciences, University of Sao Paulo, Brazil; Department of Chemical and Systems Biology, School of Medicine, Stanford University, USA. Electronic address: jcesarbf@usp.br.

PMID: 31866004
DOI: 10.1016/j.mam.2019.100836

Abstract

Disruption of mitochondrial function is a common feature of inherited mitochondrial diseases (mitochondriopathies) and many other infectious and non-infectious diseases including viral, bacterial and protozoan infections, inflammatory and chronic pain, neurodegeneration, diabetes, obesity and cardiovascular diseases. Mitochondria therefore become an attractive target for developing new therapies. In this review we describe critical mechanisms involved in the maintenance of mitochondrial functionality and discuss strategies used to identify and validate mitochondrial targets in different diseases. We also highlight the most recent preclinical and clinical findings using molecules targeting mitochondrial bioenergetics, morphology, number, content and detoxification systems in common pathologies.

Keywords: Cell signaling; Metabolism; Mitophagy; Oxidative stress; Patients; Physiology; Therapy.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cardiovascular Diseases / drug therapy
Cardiovascular Diseases / metabolism*
Energy Metabolism / drug effects
Humans
Mitochondria / drug effects
Mitochondria / metabolism*
Molecular Targeted Therapy
Oxidative Stress / drug effects