SOX2OT, a novel tumor-related long non-coding RNA

Ying Wang; Nayiyuan Wu; Xia Luo; Xiaoyun Zhang; Qianjin Liao; Jing Wang

doi:10.1016/j.biopha.2019.109725

SOX2OT, a novel tumor-related long non-coding RNA

Biomed Pharmacother. 2020 Mar:123:109725. doi: 10.1016/j.biopha.2019.109725. Epub 2019 Dec 25.

Authors

Ying Wang¹, Nayiyuan Wu², Xia Luo³, Xiaoyun Zhang², Qianjin Liao⁴, Jing Wang⁵

Affiliations

¹ Department of the Central Laboratory, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, Hunan, People's Republic of China; Hunan Clinical Research Center in Gynecologic Cancer, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, 283, Tongzipo Road, Changsha 410013, Hunan, People's Republic of China. Electronic address: wangying1171@163.com.
² Department of the Central Laboratory, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, Hunan, People's Republic of China; Hunan Clinical Research Center in Gynecologic Cancer, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, 283, Tongzipo Road, Changsha 410013, Hunan, People's Republic of China.
³ Department of the Central Laboratory, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, Hunan, People's Republic of China.
⁴ Department of the Central Laboratory, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, Hunan, People's Republic of China. Electronic address: liaoqianjin@hnszlyy.com.
⁵ Department of the Central Laboratory, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, Hunan, People's Republic of China; Hunan Clinical Research Center in Gynecologic Cancer, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, 283, Tongzipo Road, Changsha 410013, Hunan, People's Republic of China. Electronic address: wangjing0081@hnszlyy.com.

PMID: 31865145
DOI: 10.1016/j.biopha.2019.109725

Abstract

SOX2OT is a long non-coding RNA that is highly expressed in embryonic stem cells. The SOX2OT gene is comprised of 10 exons and more than two transcription start sites. Dysregulation of SOX2OT is observed in various tumors, including lung cancer, gastric cancer, esophageal cancer, breast cancer, hepatocellular carcinoma, ovarian cancer, pancreatic ductal adenocarcinoma, laryngeal squamous cell carcinoma, cholangiocarcinoma, osteosarcoma, nasopharyngeal carcinoma, and glioblastoma, wherein it typically functions as an oncogene and possibly as a tumor suppressor gene. The mechanisms underlying the effects of SOX2OT are complex and involve multiple factors and signaling pathways. In this review, we describe the current evidence regarding the role and potential clinical utility of SOX2OT in human cancers.

Keywords: Diagnostic biomarker; Long non-coding RNA; SOX2OT; Therapeutic target.

Publication types

Review

MeSH terms

Humans
Neoplasms / genetics
Neoplasms / pathology*
RNA, Long Noncoding / genetics*
Signal Transduction / genetics

Substances

RNA, Long Noncoding
long non-coding RNA Sox2ot, human