A Case-Control Study on the p73 G4A Gene Polymorphism and Susceptibility to Breast Cancer in an Iranian Population

Zeinab Tavakkol Afshari; Zahra Gholizadeh; Amin Reza Nikpoor; Jalil Tavakkol Afshari; Rashin Ganjali; Fatemeh Homaei Shandiz; Khadijeh Jamialahmadi

A Case-Control Study on the p73 G4A Gene Polymorphism and Susceptibility to Breast Cancer in an Iranian Population

Iran J Public Health. 2019 Oct;48(10):1855-1860.

Authors

Zeinab Tavakkol Afshari¹, Zahra Gholizadeh^{1

2}, Amin Reza Nikpoor³, Jalil Tavakkol Afshari^{1

2}, Rashin Ganjali¹, Fatemeh Homaei Shandiz⁴, Khadijeh Jamialahmadi^{5

6}

Affiliations

¹ Department of Immunogenetic and Cell Culture, Immunology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
² Department of Allergy and Immunology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
³ Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
⁴ Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
⁵ Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
⁶ Department of Medical Biotechnology and Nanotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

PMID: 31850263
PMCID: PMC6908912

Abstract

Background: The tumor protein p73 (TP73) is a homolog of TP53 family. Ectopic p73 overexpression largely mimics p53 activities as a tumor suppressor and activates the transcription of p53-responsive genes and as a result induce apoptosis. This study aimed to investigate the association between p73 G4A polymorphism and the risk of breast cancer in a northeastern Iranian population.

Methods: This case-control study was performed on 105 patients who admitted in educational hospitals of Mashhad University of Medical Sciences, Iran during 2013-2015, with breast cancer as case group and 120 healthy women as the control group. PCR-CTPP method was used to investigate the relationship between the p73 G4A polymorphism and the risk of breast cancer.

Results: There was no significant association between the AA genotype of the p73 G4A polymorphism and breast cancer in case and control groups. Although G allele frequency was higher in the case group, the abundance of this allele between case and control groups was not statistically meaningful and, as a result, not associated with the risk of breast cancer in this study group.

Conclusion: There was no association between G4A p73 polymorphism and the risk of breast cancer in a northeastern Iranian population.

Keywords: Breast cancer; Polymorphism; Tumor protein p73.