Over-diagnosis of Rotavirus Infection in Infants Due to Detection of Vaccine Virus

David M Whiley; Suifang Ye; Sarah Tozer; Julia E Clark; Cheryl Bletchly; Stephen B Lambert; Keith Grimwood; Graeme R Nimmo

doi:10.1093/cid/ciz1196

Over-diagnosis of Rotavirus Infection in Infants Due to Detection of Vaccine Virus

Clin Infect Dis. 2020 Aug 22;71(5):1324-1326. doi: 10.1093/cid/ciz1196.

Authors

David M Whiley^{1

2}, Suifang Ye^{2

3}, Sarah Tozer⁴, Julia E Clark⁵, Cheryl Bletchly⁶, Stephen B Lambert⁴, Keith Grimwood^{7

8}, Graeme R Nimmo⁶

Affiliations

¹ Faculty of Medicine, University of Queensland Centre for Clinical Research, The University of Queensland, Brisbane, Queensland, Australia.
² Microbiology Division, Pathology Queensland Central Laboratory, Brisbane, Queensland, Australia.
³ University of Queensland Centre for Clinical Research, The University of Queensland, Brisbane, Queensland, Australia.
⁴ Child Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia.
⁵ Queensland Children's Hospital, Child Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia.
⁶ Pathology Queensland Central Laboratory, Brisbane, Queensland, Australia.
⁷ The School of Medicine and Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, Australia.
⁸ Departments of Paediatrics and Infectious Diseases, Gold Coast Health, Gold Coast, Queensland, Australia.

PMID: 31848594
DOI: 10.1093/cid/ciz1196

Abstract

An accurate rotavirus diagnosis is important for clinical management and monitoring active disease and vaccine effectiveness. Between 2016-2018, rotavirus-positive results in our laboratory were from vaccine virus shedding in 71/152 (46.7%) infants with a request for rotavirus testing. Routine infant diagnostic testing should ideally distinguish vaccine from wild-type viruses.

Keywords: diagnosis; rotavirus; shedding; vaccine.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cowpox virus
Feces
Humans
Infant
Medical Overuse
Rotavirus Infections* / diagnosis
Rotavirus Infections* / prevention & control
Rotavirus Vaccines*
Rotavirus* / genetics
Vaccines, Attenuated

Substances

Rotavirus Vaccines
Vaccines, Attenuated