A proposed method for the calculation of age-dependent QRS duration z-scores

Henry Chubb; Scott R Ceresnak; Kara S Motonaga; Anne M Dubin

doi:10.1016/j.jelectrocard.2019.12.004

A proposed method for the calculation of age-dependent QRS duration z-scores

J Electrocardiol. 2020 Jan-Feb:58:132-134. doi: 10.1016/j.jelectrocard.2019.12.004. Epub 2019 Dec 6.

Authors

Henry Chubb¹, Scott R Ceresnak², Kara S Motonaga², Anne M Dubin²

Affiliations

¹ Division of Pediatric Cardiology, Department of Pediatrics, Stanford University, Palo Alto, CA, USA; Department of Cardiothoracic Surgery, Stanford University School of Medicine, 780 Welch Road, Stanford, CA 9430, USA. Electronic address: mhchubb@stanford.edu.
² Division of Pediatric Cardiology, Department of Pediatrics, Stanford University, Palo Alto, CA, USA.

PMID: 31846856
DOI: 10.1016/j.jelectrocard.2019.12.004

Abstract

Background: There are currently no published algorithms for calculation of age-dependent QRS duration z-scores. The absence of a standardized measure has limited researchers' abilities to compare ECG measurements of electrical synchrony between subjects of different ages or longitudinally over time.

Methods: Four existing studies of normal ECG measurements (total 19,062 subjects) were used to estimate age and sex-dependent means and standard deviations.

Results: Weighted means and standard deviations were best estimated by cubic functions to create z-score algorithms.

Conclusion: Nomograms and algorithms for QRS duration z-scores may be estimated to compare ECG findings in both children and adults.

Keywords: Cardiac resynchronization therapy; Dyssynchrony; Electrocardiogram; Pediatric cardiology; Z-score.

MeSH terms

Child
Electrocardiography*
Humans