The role of increased red cell distribution width as a negative prognostic marker in patients with COPD

Abstract

Introduction: Chronic obstructive pulmonary disease (COPD) remains a major burden with no clinically applicable biomarkers.

Aim: To investigate the association of Red cell Distribution Width (RDW) values on admission with previous hospitalizations, need of non-invasive mechanical ventilation (NIMV) and long term oxygen therapy (LTOT) in patients with COPD.

Methods: Patients with AECOPD admitted to our department during 2018 were included in the study.

Results: One hundred sixty patients were enrolled (M/F 95/65, median age 71.00 years, mean FEV₁± SD = 46.6 ± 28.9). Median RDW was significantly higher for patients in need of NIMV (14.8, 95% CI: 14.2 to 15.6) than patients not in need of NIMV (13.5, 95% CI: 13.2 to 13.8) (p < 0.001). Median RDW was significantly higher for patients in need of LTOT (14.2, 95% CI: 13.7 to 14.6) compared to patients not receiving LTOT (13.2, 95% CI: 12.5 to 13.6) (p = 0.001). Patients with hospitalization during the last 12 months had increased RDW values compared to patients with no hospitalizations [median RDW 14.3, (95% CI: 13.5 to 14.9) versus median RDW 13.5, (95% CI: 13.1 to 13.9)](p = 0.001).

Conclusion: Patients with COPD in need of LTOT, NIMV or patients with previous hospitalizations presented with increased RDW values. Increased RDW values could serve as a negative prognostic marker in patients with COPD.

Keywords: Biomarkers; Chronic obstructive pulmonary disease; Hospitalizations; Long term oxygen therapy; Non-invasive mechanical ventilation; Red cell distribution width.