RCC2 promotes breast cancer progression through regulation of Wnt signaling and inducing EMT

Zhen Chen; Wenjing Wu; Yongsheng Huang; Limin Xie; Yu Li; Hengxing Chen; Wenjia Li; Dong Yin; Kaishun Hu

doi:10.7150/jca.36430

RCC2 promotes breast cancer progression through regulation of Wnt signaling and inducing EMT

J Cancer. 2019 Nov 1;10(27):6837-6847. doi: 10.7150/jca.36430. eCollection 2019.

Authors

Zhen Chen¹, Wenjing Wu², Yongsheng Huang¹, Limin Xie¹, Yu Li¹, Hengxing Chen¹, Wenjia Li¹, Dong Yin¹, Kaishun Hu¹

Affiliations

¹ Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.
² Department of Breast Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.

Abstract

Regulator of chromosome condensation 2 (RCC2), also known as TD-60, is an RCC1 family member and plays an essential role in mitosis. However, the roles of RCC2 in breast cancer are still unclear. In this study, RCC2 was found to exert oncogenic activities in breast cancer. Samples of breast cancer tissue revealed an increased level of RCC2 and a high level of RCC2 was associated with poor overall survival rate of breast cancer patients. Overexpression of RCC2 significantly enhanced cell proliferation and migration abilities of breast cancer cells in vitro and in vivo. Mechanistically, RCC2 induced epithelial-mesenchymal transition (EMT) through the activation of Wnt signaling pathway. Collectively, our study indicates that RCC2 contributes to breast cancer progression and functions as an important regulator of EMT through the activation of Wnt signaling.

Keywords: Breast cancer; Epithelial-Mesenchymal Transition (EMT); Regulator of Chromosome Condensation 2 (RCC2); Wnt signaling pathway.