Interaction of particles with mucosae and cell membranes

Shaohuang Chen; Huxiang Guo; Mei Cui; Renliang Huang; Rongxin Su; Wei Qi; Zhimin He

doi:10.1016/j.colsurfb.2019.110657

Interaction of particles with mucosae and cell membranes

Colloids Surf B Biointerfaces. 2020 Feb:186:110657. doi: 10.1016/j.colsurfb.2019.110657. Epub 2019 Nov 22.

Authors

Shaohuang Chen¹, Huxiang Guo², Mei Cui², Renliang Huang³, Rongxin Su⁴, Wei Qi⁵, Zhimin He²

Affiliations

¹ Tianjin Key Laboratory of Indoor Air Environmental Quality Control, School of Environmental Science and Engineering, Tianjin University, Tianjin, 300072, PR China; State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, PR China.
² State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, PR China.
³ Tianjin Key Laboratory of Indoor Air Environmental Quality Control, School of Environmental Science and Engineering, Tianjin University, Tianjin, 300072, PR China. Electronic address: tjuhrl@tju.edu.cn.
⁴ State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, PR China; Tianjin Key Laboratory of Membrane Science and Desalination Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, PR China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, PR China; School of Marine Science and Technology, Tianjin University, Tianjin 300072, PR China. Electronic address: surx@tju.edu.cn.
⁵ State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, PR China; Tianjin Key Laboratory of Membrane Science and Desalination Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, PR China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, PR China.

PMID: 31835181
DOI: 10.1016/j.colsurfb.2019.110657

Abstract

The fates and detrimental effects of particles entering the body have gained increasingly notable attention worldwide because of the burgeoning applications of various particles and wide existence of ambient particulate matter. Studies on the interaction of particles with biological interfaces demonstrate the potential risks and hazards to the health of living organisms. This review aims to provide a systematic overview of the interaction between particles and typical biological interfaces, with an emphasis on the effects of particle properties and microenvironment, and the potential adverse results arising from these interactions. First, we describe the major entry routes of particles into the human body to understand the main exposure pathways and the fates and impacts of particles. Different behaviors of particles interacting with mucosae and cell membranes are then reviewed. Finally, the knowledge gaps are identified and the long-term development of interaction research is proposed.

Keywords: Cell membranes; Interaction; Mucins; Mucosae; Particles.

Publication types

Review

MeSH terms

Animals
Cell Membrane / chemistry*
Humans
Mucous Membrane / chemistry*
Particle Size
Surface Properties