The Remarkable Journey of a Low-Frequency Alloantibody

Adrian Bachofner; Tanja Rüfli; Andreas Holbro; Hein Hustinx; Sofia Lejon Crottet; Matyas Escedi; Andreas Buser; Laura Infanti

doi:10.1159/000490503

The Remarkable Journey of a Low-Frequency Alloantibody

Transfus Med Hemother. 2019 Oct;46(5):384-385. doi: 10.1159/000490503. Epub 2019 Jan 29.

Authors

Adrian Bachofner^{1

2}, Tanja Rüfli², Andreas Holbro^{1

2}, Hein Hustinx³, Sofia Lejon Crottet³, Matyas Escedi^{1

2}, Andreas Buser^{1

2}, Laura Infanti^{1

2}

Affiliations

¹ Regional Blood Transfusion Center, Swiss Red Cross, Basel, Switzerland.
² Division of Hematology, University Hospital Basel, Basel, Switzerland.
³ Swiss Immunohematology Reference Laboratory, Interregional Blood Transfusion, Swiss Red Cross, Basel, Switzerland.

Abstract

Herein we describe a case of febrile non-hemolytic reaction (FNHTR) in a 64-year-old male 20 min after the transfusion of one red blood cell unit. 20 days prior the patient had undergone an allogeneic hematopoietic stem cell transplantation (HCT) from an unrelated donor with minor ABO disparity. The patient had been treated for plasma cell myeloma with multiple transfusions in the past, but no transfusion reactions or alloimmunization had been reported.

Keywords: Alloimmunization; Anti-Diego A; Blood transfusion; Low-frequency alloantibody.

Publication types

Case Reports