Research progresses of molecular mechanism of pyroptosis and its related diseases

Weihua Gong; Ying Shi; Jingjing Ren

doi:10.1016/j.imbio.2019.11.019

Research progresses of molecular mechanism of pyroptosis and its related diseases

Immunobiology. 2020 Mar;225(2):151884. doi: 10.1016/j.imbio.2019.11.019. Epub 2019 Dec 3.

Authors

Weihua Gong¹, Ying Shi², Jingjing Ren¹

Affiliations

¹ Clinical Laboratory, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
² Clinical Laboratory, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Department of Clinical Immunology, Zhengzhou University, Zhengzhou 450052, China. Electronic address: 15037169625@126.com.

PMID: 31822435
DOI: 10.1016/j.imbio.2019.11.019

Abstract

Pyroptosis is a newly discovered untypical form of programmed cell death by inflammatory response, which is dependent on the classic pathway of Caspase-1 and the non-canonical pathway of Caspase-11 in mice or orthologue Caspase-4/-5 in Humans. It has been found that the Gasdermin family of protein is a key molecule in the formation of membrane pores of pyroptosis. After being cleaved by inflammatory caspases, it releases a N-terminal fragment with perforating activity to trigger pyroptosis. That pyroptosis is closely related to the occurrence and development of certain diseases. Now, the molecular mechanism of pyroptosis and pyroptosis-related diseases are reviewed.

Keywords: Caspase; Gasdermin; Pyroptosis.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Apoptosis / physiology*
Caspases / metabolism
Humans
Inflammation / metabolism
Inflammation / pathology
Pyroptosis / physiology*

Substances

Caspases