TRIM proteins in neuroblastoma

Yonghu Xu; Zihan Zhang; Guofeng Xu

doi:10.1042/BSR20192050

TRIM proteins in neuroblastoma

Biosci Rep. 2019 Dec 20;39(12):BSR20192050. doi: 10.1042/BSR20192050.

Authors

Yonghu Xu¹, Zihan Zhang¹, Guofeng Xu¹

Affiliation

¹ Department of Pediatric Urology, Xinhua Hospital, National Key Clinical Specialty, Shanghai Top-Priority Clinical Center, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, China.

Abstract

Neuroblastoma (NB) is the most common extracranial solid tumor in childhood. Outcome for children with high-risk NB remains unsatisfactory. Accumulating evidence suggests that tripartite motif (TRIM) family proteins express diversely in various human cancers and act as regulators of oncoproteins or tumor suppressor proteins. This review summarizes the TRIM proteins involving in NB and the underlying molecular mechanisms. We expect these new insights will provide important implications for the treatment of NB by targeting TRIM proteins.

Keywords: E3 ubiquitin ligase; TRIM proteins; neuroblastoma; ubiquitination.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Humans
Neuroblastoma / genetics*
Neuroblastoma / pathology
Tripartite Motif Proteins / genetics*
Tumor Suppressor Proteins / genetics*
Ubiquitin-Protein Ligases / genetics
Ubiquitination / genetics*

Substances

Tripartite Motif Proteins
Tumor Suppressor Proteins
Ubiquitin-Protein Ligases