Advances In Research Of Spreading Through Air Spaces And The Effects On The Prognosis Of Lung Cancer

Dandan Cao; Jun Sha; Rui Cui; Shuhua Han

doi:10.2147/CMAR.S232187

Advances In Research Of Spreading Through Air Spaces And The Effects On The Prognosis Of Lung Cancer

Cancer Manag Res. 2019 Nov 15:11:9725-9732. doi: 10.2147/CMAR.S232187. eCollection 2019.

Authors

Dandan Cao^{1

2}, Jun Sha^{1

2}, Rui Cui^{1

2}, Shuhua Han¹

Affiliations

¹ Department of Pulmonary Medicine, Zhongda Hospital, School of Medicine, South-East University, Nanjing, Jiangsu, People's Republic of China.
² Medicine Department of Southeast University, Nanjing, Jiangsu, People's Republic of China.

Abstract

The concept of spread through air spaces (STAS) has been described as a new form of invasion in the lung in the 2015 WHO classiﬁcation of Lung Tumors, namely invasion through alveolar spaces. STAS is a prognostic factor independent of growth pattern and tumor stage, and it is also an independent risk factor for unfavorable prognosis of stage I lung adenocarcinoma (ADC) and stage I lung squamous cell carcinoma (SCC). The pathological characteristics are different between ADC and SCC. STAS is not reported as routine, so setting a unified pathological reading standard, and hunting for STAS as a regular reading process is urgently advocated. We write this review to investigate the research progress of STAS and its effects on the prognosis of lung cancer.

Keywords: STAS; lung cancer; pathological characteristics; prognosis.

Publication types

Review