Glucose-Sensing Neurons Reciprocally Regulate Insulin and Glucagon

Zepeng Yao; Kristin Scott

doi:10.1016/j.tins.2019.11.006

Glucose-Sensing Neurons Reciprocally Regulate Insulin and Glucagon

Trends Neurosci. 2020 Jan;43(1):2-5. doi: 10.1016/j.tins.2019.11.006. Epub 2019 Dec 5.

Authors

Zepeng Yao¹, Kristin Scott²

Affiliations

¹ Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
² Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA. Electronic address: kscott@berkeley.edu.

Abstract

A recent paper by Oh et al. identified a single pair of neurons in the fruit fly brain that directly senses 'blood' glucose levels and reciprocally regulates the secretion of insulin and glucagon. This study provides insight into how the brain regulates the circulation and storage of glucose.

Keywords: glucose sensing; homeostasis; neuropeptides.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Drosophila
Glucagon*
Glucose
Insulin*
Neurons

Substances

Insulin
Glucagon
Glucose

Grants and funding

R01 GM128209/GM/NIGMS NIH HHS/United States