Migrastatics: Redirecting R&D in Solid Cancer Towards Metastasis?

Trends Cancer. 2019 Dec;5(12):755-756. doi: 10.1016/j.trecan.2019.10.011. Epub 2019 Nov 16.

Abstract

The concept of 'migrastatics' allows the development of a new drug class that is neither cytotoxic nor antiproliferative but is solely directed towards inhibition of cancer cell motility. Given that the regulatory pathway is open, and migrastatic candidates have been described, it is the right time to enter a new era of antimetastatic treatment.

Keywords: cancer therapy; invasiveness; metastasis; migrastatic treatment.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Line, Tumor
  • Humans
  • Neoplasm Invasiveness / genetics*
  • Neoplasm Metastasis
  • Neoplasms / complications*