A Deep Learning Framework for Design and Analysis of Surgical Bioprosthetic Heart Valves

Sci Rep. 2019 Dec 6;9(1):18560. doi: 10.1038/s41598-019-54707-9.

Abstract

Bioprosthetic heart valves (BHVs) are commonly used as heart valve replacements but they are prone to fatigue failure; estimating their remaining life directly from medical images is difficult. Analyzing the valve performance can provide better guidance for personalized valve design. However, such analyses are often computationally intensive. In this work, we introduce the concept of deep learning (DL) based finite element analysis (DLFEA) to learn the deformation biomechanics of bioprosthetic aortic valves directly from simulations. The proposed DL framework can eliminate the time-consuming biomechanics simulations, while predicting valve deformations with the same fidelity. We present statistical results that demonstrate the high performance of the DLFEA framework and the applicability of the framework to predict bioprosthetic aortic valve deformations. With further development, such a tool can provide fast decision support for designing surgical bioprosthetic aortic valves. Ultimately, this framework could be extended to other BHVs and improve patient care.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Biomechanical Phenomena
  • Bioprosthesis / adverse effects*
  • Computer-Aided Design*
  • Decision Support Techniques
  • Deep Learning*
  • Feasibility Studies
  • Finite Element Analysis
  • Heart Valve Prosthesis / adverse effects*
  • Heart Valve Prosthesis Implantation / adverse effects
  • Heart Valve Prosthesis Implantation / instrumentation
  • Heart Valves / diagnostic imaging
  • Heart Valves / physiology
  • Humans
  • Image Processing, Computer-Assisted / methods
  • Models, Cardiovascular
  • Prosthesis Design / methods*
  • Prosthesis Failure
  • Tomography, X-Ray Computed