Examining Race-Related Error in Two-Compartment Models of Body Composition Assessment: A Systematic Review and Meta-Analysis

Abstract

Background: The Brozek and Siri formulas estimate relative adiposity (%Fat) from total body density (D_b) using a 2-compartment (2C) model. Racial/ethnic differences in D_b have been reported, along with subsequent errors in estimated %Fat.

Objective: The primary aim of this systematic review and meta-analysis was to examine potential race/ethnic differences in the accuracy of the Brozek and Siri 2C formulas using aggregate-level data.

Methods: Peer-reviewed studies available in English that provided 2C and 4C estimates of %Fat were located using searches of the PubMed (n = 150), Scopus (n = 170), and Web of Science (n = 138) online electronic databases. Random-effects models were used to determine potential differences between racial groups using a mean ES and 95% confidence intervals.

Results: The cumulative results from 78 effects indicate that the relative accuracy of the Brozek equation did not vary between racial groups (between group p = 0.053). In contrast, the Siri equation slightly underestimated %Fat for Asian adults (ES_WMD = -1.40%, 95%CI -2.33% to -0.46%; p = 0.004) and Black adults (ES_WMD = -1.10%, 95%CI -2.11% to -0.08%; p = 0.034), with no significant differences observed in Hispanic adults (ES_WMD = 0.64%, 95%CI -1.02% to 2.31%; p = 0.448) and White adults (ES_WMD = 0.08%, 95%CI -0.42% to 0.57%; p = 0.766) (between group p = 0.019).

Conclusion: Small, but statistically significant, error was found between racial groups when estimating %Fat using the 2C Siri equation when compared to 4C models. However, the observed error due to race/ethnicity appears to be of little clinical or practical significance when using either equation.

Keywords: 2-compartment; Body composition; body density; race differences.