Optical pico-biosensing of lead using plasmonic gold nanoparticles and a cationic peptide-based aptasensor

Manju Solra; Rajni Bala; Nishima Wangoo; Gurpreet K Soni; Munish Kumar; Rohit K Sharma

doi:10.1039/c9cc07407d

Optical pico-biosensing of lead using plasmonic gold nanoparticles and a cationic peptide-based aptasensor

Chem Commun (Camb). 2019 Dec 19;56(2):289-292. doi: 10.1039/c9cc07407d.

Authors

Manju Solra¹, Rajni Bala, Nishima Wangoo, Gurpreet K Soni, Munish Kumar, Rohit K Sharma

Affiliation

¹ Department of Chemistry and Centre of Advanced Studies in Chemistry, Panjab University, Sector-14, Chandigarh 160014, India. rohitksg@pu.ac.in.

PMID: 31808471
DOI: 10.1039/c9cc07407d

Abstract

A novel biosensor for the rapid detection of lead ions employing the optical properties of AuNPs, a lead-specific aptamer and a cationic peptide has been demonstrated. The limit of detection of the biosensor was 98.7 pM, the lowest so far obtained using colorimetry.

MeSH terms

Aptamers, Nucleotide / chemistry*
Biosensing Techniques / methods
Color
Colorimetry / methods*
DNA / chemistry
Gold / chemistry
Lead / analysis*
Limit of Detection
Metal Nanoparticles / chemistry*
Peptides / chemistry*
Surface Plasmon Resonance / methods

Substances

Aptamers, Nucleotide
Peptides
Lead
Gold
DNA