Bivalent AMPA receptor positive allosteric modulators of the bis(pyrimidine) series

Anna A Nazarova; Kseniya N Sedenkova; Dmitry S Karlov; Mstislav I Lavrov; Yuri K Grishin; Tamara S Kuznetsova; Vladimir L Zamoyski; Vladimir V Grigoriev; Elena B Averina; Vladimir A Palyulin

doi:10.1039/c9md00262f

Bivalent AMPA receptor positive allosteric modulators of the bis(pyrimidine) series

Medchemcomm. 2019 Jul 12;10(9):1615-1619. doi: 10.1039/c9md00262f. eCollection 2019 Sep 1.

Authors

Anna A Nazarova¹, Kseniya N Sedenkova^{1

2}, Dmitry S Karlov^{1

3}, Mstislav I Lavrov^{1

2}, Yuri K Grishin¹, Tamara S Kuznetsova¹, Vladimir L Zamoyski², Vladimir V Grigoriev^{1

2}, Elena B Averina^{1

2}, Vladimir A Palyulin^{1

2}

Affiliations

¹ Department of Chemistry , Lomonosov Moscow State University , 119991 Moscow , Russian Federation . Email: elaver@med.chem.msu.ru ; Email: vap@qsar.chem.msu.ru.
² Institute of Physiologically Active Compounds , Russian Academy of Sciences , 142432 Chernogolovka , Moscow Region , Russian Federation.
³ Center for Computational and Data-intensive Science and Engineering , Skolkovo Institute of Science and Technology , 121205 Moscow , Russian Federation.

Abstract

The first example of a novel class of AMPA receptor positive allosteric modulators of the bis(pyrimidine) series having a hydroquinone linker has been obtained and showed a potency to increase kainate-induced currents at subnanomolar concentrations.