Geotrichum capitatum Invasive Infection Early After Liver Transplant

Exp Clin Transplant. 2020 Nov;18(6):737-740. doi: 10.6002/ect.2019.0170. Epub 2019 Nov 29.

Abstract

Geotrichum capitatum is a rare fungal pathogen that has infrequently affected immunocompromised patients with onco-hematologic diseases. Geotrichum capitatum invasive infection has been associated with poor prognosis, with a mortality rate ranging from 50% to 90%. Here, we report the first case of Geotrichum capitatum invasive fungal infection in a liver transplant recipient from an unrelated deceased donor, who was effectively treated with amphotericin B and voriconazole. We also reviewed the available literature in the field.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Amphotericin B / therapeutic use
  • Antifungal Agents / therapeutic use
  • Fatal Outcome
  • Humans
  • Immunocompromised Host
  • Immunosuppressive Agents / adverse effects
  • Invasive Fungal Infections / diagnosis
  • Invasive Fungal Infections / drug therapy
  • Invasive Fungal Infections / microbiology*
  • Liver Transplantation / adverse effects*
  • Male
  • Middle Aged
  • Multiple Organ Failure / etiology
  • Opportunistic Infections / diagnosis
  • Opportunistic Infections / drug therapy
  • Opportunistic Infections / microbiology*
  • Saccharomycetales / drug effects
  • Saccharomycetales / pathogenicity*
  • Sepsis / complications
  • Sepsis / immunology
  • Sepsis / microbiology
  • Treatment Outcome
  • Voriconazole / therapeutic use

Substances

  • Antifungal Agents
  • Immunosuppressive Agents
  • Amphotericin B
  • Voriconazole

Supplementary concepts

  • Magnusiomyces capitatus