Erythroferrone lowers hepcidin by sequestering BMP2/6 heterodimer from binding to the BMP type I receptor ALK3

Blood. 2020 Feb 6;135(6):453-456. doi: 10.1182/blood.2019002620.

Authors

Chia-Yu Wang¹, Yang Xu¹, Lisa Traeger^{2

3}, Deniz Y Dogan², Xia Xiao¹, Andrea U Steinbicker², Jodie L Babitt¹

Affiliations

¹ Division of Nephrology, Program in Membrane Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
² Department of Anesthesiology, Intensive Care and Pain Medicine, University of Muenster, Muenster, Germany; and.
³ Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Bone Morphogenetic Protein 2 / metabolism*
Bone Morphogenetic Protein 6 / metabolism*
Bone Morphogenetic Protein Receptors, Type I / metabolism*
Cells, Cultured
Cytokines / metabolism*
HEK293 Cells
Hepatocytes / metabolism
Hepcidins / metabolism*
Humans
Mice
Mice, Inbred C57BL
Muscle Proteins / metabolism*
Protein Multimerization

Substances

Bmp2 protein, mouse
Bmp6 protein, mouse
Bone Morphogenetic Protein 2
Bone Morphogenetic Protein 6
Cytokines
Erfe protein, mouse
Hepcidins
Muscle Proteins
Bmpr1a protein, mouse
Bone Morphogenetic Protein Receptors, Type I

Grants and funding

R01 DK087727/DK/NIDDK NIH HHS/United States