Expression profiling dataset of competing endogenous RNA in pre-eclampsia

Xiaopeng Hu; Xinyue Li; Geng G Tian; Huijuan Zhang; Weiwei Cheng; Ji Wu

doi:10.1016/j.dib.2019.104795

Expression profiling dataset of competing endogenous RNA in pre-eclampsia

Data Brief. 2019 Nov 12:27:104795. doi: 10.1016/j.dib.2019.104795. eCollection 2019 Dec.

Authors

Xiaopeng Hu^{1

2

3

4}, Xinyue Li¹, Geng G Tian¹, Huijuan Zhang², Weiwei Cheng², Ji Wu^{1

3

4}

Affiliations

¹ Bio-X Institutes, Shanghai Jiao Tong University, Shanghai, 200240, China.
² International Peace Maternity & Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
³ Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Ningxia Medical University, Yinchuan, 750004, China.
⁴ Shanghai Key Laboratory of Reproductive Medicine, Shanghai, 200025, China.

Abstract

This data descriptor is an extended version of the methodologies which have been described in a related paper [1]; its purpose is to disseminate the raw data and analyzed data produced in this experiment. For more insight please see the research article, "competing endogenous RNA expression profiling in pre-eclampsia identifies hsa_circ_0036877 as a potential novel blood biomarker for early pre-eclampsia" (Xiaopeng Hu and Junping Ao, 2018) [1]. Using microarray analysis, we investigated competing endogenous RNA (ceRNA) expression profiles in placentas of women with severe pre-eclampsia (SPE) and normal pregnancies. Competing endogenous RNA (ceRNA) refer to RNA transcripts, such as messenger RNA (mRNA), long noncoding RNA (lncRNA), and circular RNA (circRNA) that can regulate each other by competing for the same pool of miRNAs. CircRNAs, lncRNAs, and mRNAs differentially expressed between human normal and SPE placentas were obtained in the study. Metadata files were submitted to the Gene Expression Omnibus repository (GEO), with GEO accession number GSE102897. These data are potential useful for further study on the pathogenesis of PE and early prediction of PE onset.

Keywords: Competing endogenous RNA; Expression profiling dataset; Pre-eclampsia; circRNA; lncRNA; mRNA.