Objectives:The aim of this CBCT study was to evaluate the postoperative volume changes of the rhinosinusal airway space, maxillary sinuses and nasal fossa, that occur after Le Fort I osteotomy, using individual segmentation of 3D virtual models. Material and methods:A number of 16 patients (with Class II and Class III malocclusions) who underwent a CBCT examination for orthognathic surgery at six month-interval between preoperative and postoperative evaluations were included. Patients with thickening of the sinus mucosa, craniofacial syndromes, maxillofacial trauma, rhinoplasty or other maxillofacial pathological conditions were excluded from the study. Individual segmentation of airway volumes was performed by the ITK-SNAP 2.0 software. Paired student t-test was used for the statistical examination of volume changes and Pearson's test for the assessment of intra-rate correlation. Outcomes:A statistically significant decrease in the rhinosinusal volume in Class II (9.36±3.43 cm3) and Class III malocclusions (3.65±2.96 cm3) was found after Le Fort I osteotomy. A decrease in volume was also found for maxillary sinuses (5.63±1.52 cm3 for Class II and 6.72±4.5 cm3 for Class III malocclusion). Nasal fossa decreased in volume (3.79±3.8 cm3) in Class II malocclusion patients and increased (3.07±2.39 cm3) in Class III malocclusion patients. The Pearson correlation revealed a high intra-rate agreement of measurements. Conclusion:Le Fort I osteotomy modifies the postoperative volume of rhinosinusal aerial spaces and individual segmentation on CBCT images is a useful tool to analyze the changes.