Calcium & ROS: Two orchestra directors for the requiem of death

Cell Calcium. 2020 Jan:85:102113. doi: 10.1016/j.ceca.2019.102113. Epub 2019 Nov 25.

Abstract

Tumor necrosis factor alpha (TNF) triggers regulated necrosis of mycobacterium-infected macrophages through of mitochondrial reactive oxygen species (mitoROS) production in a RIPK1/3-dependent manner. To explain that, Roca and colleagues describe an inter-orgallenar circuit which involves the lysosomal ceramide production, mitoROS, BAX activation and RyR Ca2+ efflux from the endoplasmic reticulum into the mitochondrion.

Keywords: Calcium; Mycobacterium tuberculosis; ROS; Regulated necrosis; Ryanodine receptor; TNF.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Calcium / metabolism*
  • Calcium Signaling
  • Cell Death
  • Humans
  • Models, Biological
  • Reactive Oxygen Species / metabolism*
  • Ryanodine Receptor Calcium Release Channel / metabolism

Substances

  • Reactive Oxygen Species
  • Ryanodine Receptor Calcium Release Channel
  • Calcium