Reporting and analyses of sex/gender and race/ethnicity in randomized controlled trials of interventions published in the highest-ranking anesthesiology journals

J Comp Eff Res. 2019 Dec;8(16):1417-1423. doi: 10.2217/cer-2019-0071. Epub 2019 Dec 2.

Abstract

Aim: We assessed reporting of data on sex/gender and race/ethnicity in randomized controlled trials of interventions published in the highest-ranking anesthesiology journals from 2014 to 2017. Methods: We extracted data regarding terminology for sex/gender, proportion of participants according to the race/gender and race/ethnicity, and results shown for the race/gender and race/ethnicity. Results: Among the analyzed 732 trials, few stratified allocation of participants on the basis of sex/gender and race/ethnicity, few reported results for sex/gender or race/ethnicity and the outcomes reported may be influenced by one or both. Conclusion: In conclusion, outcomes of anesthesiology trials could be vulnerable to an important and avoidable source of bias; trialists need to pay more attention to sex and race/ethnicity when designing and reporting their studies.

Keywords: gender; randomized controlled trial; sex; terminology.

MeSH terms

  • Anesthesiology / statistics & numerical data*
  • Ethnicity / statistics & numerical data*
  • Female
  • Humans
  • Male
  • Periodicals as Topic / statistics & numerical data*
  • Publications / statistics & numerical data
  • Randomized Controlled Trials as Topic / statistics & numerical data*
  • Research Design / statistics & numerical data
  • Sex Distribution