New insights on T-cell self-tolerance

Jaeu Yi; Takeshi Kawabe; Jonathan Sprent

doi:10.1016/j.coi.2019.10.002

New insights on T-cell self-tolerance

Curr Opin Immunol. 2020 Apr:63:14-20. doi: 10.1016/j.coi.2019.10.002. Epub 2019 Nov 28.

Authors

Jaeu Yi¹, Takeshi Kawabe², Jonathan Sprent³

Affiliations

¹ Division of Rheumatology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
² Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980-8575, Japan.
³ Immunology Division, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia; St. Vincent's Clinical School, University of New South Wales, Sydney, NSW 2010, Australia. Electronic address: j.sprent@garvan.org.au.

PMID: 31786417
DOI: 10.1016/j.coi.2019.10.002

Abstract

Self-tolerance of T cells is maintained by a combination of thymic negative selection and suppression by T regulatory cells (Tregs); both processes are driven by recognition of self MHC ligands. Treg function ensures that most T cells remain quiescent as naïve cells, but enables some T cells to proliferate and differentiate into cells with a memory phenotype (MP). In this review, we discuss how Tregs shape this compartmentalization of T cells into subsets of naïve and MP T cells.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Differentiation / immunology
Humans
Immunologic Memory / immunology
Phenotype
Self Tolerance / immunology*
T-Lymphocytes, Regulatory / immunology*