RETRACTED: Human bone mesenchymal stem cells-derived exosomes overexpressing microRNA-26a-5p alleviate osteoarthritis via down-regulation of PTGS2

Int Immunopharmacol. 2020 Jan:78:105946. doi: 10.1016/j.intimp.2019.105946. Epub 2019 Nov 26.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor-in-Chief. Concern was raised about the reliability of the Western blot results in Figures 2E, 3D and F, 4B, E+G, 5D+I, and 6D+F, which appear to have a similar phenotype as contained in many other publications, detailed here: https://pubpeer.com/publications/73C0A79F5EDF9ECC9818CE2D9B2A09; and here: https://docs.google.com/spreadsheets/d/1r0MyIYpagBc58BRF9c3luWNlCX8VUvUuPyYYXzxWvgY/edit#gid=262337249. The provenance of the flow cytometry data in Figure 5A was also questioned, as it appeared to have histograms that were hand drawn. The journal requested the corresponding author comment on these concerns and provide the raw data. The authors did not respond to this request and therefore the Editor-in-Chief decided to retract the article.

Keywords: Human bone mesenchymal stem cells; Osteoarthritis; PTGS2; Synovial fibroblasts; microRNA-26a-5p.

Publication types

  • Retracted Publication

MeSH terms

  • Aged
  • Animals
  • Bone and Bones / cytology
  • Cells, Cultured
  • Cyclooxygenase 2 / genetics*
  • Cytokines / genetics
  • Cytokines / metabolism
  • Down-Regulation
  • Exosomes / genetics*
  • Female
  • Fibroblasts / metabolism
  • Fibroblasts / pathology
  • Humans
  • Male
  • Mesenchymal Stem Cells / metabolism
  • MicroRNAs / antagonists & inhibitors
  • MicroRNAs / genetics*
  • Middle Aged
  • Osteoarthritis / genetics*
  • Osteoarthritis / metabolism
  • Rats, Wistar
  • Synovial Membrane
  • Up-Regulation

Substances

  • Cytokines
  • MIRN26A microRNA, human
  • MicroRNAs
  • Cyclooxygenase 2
  • PTGS2 protein, human