Update on Myopia Risk Factors and Microenvironmental Changes

Valeria Coviltir; Miruna Burcel; Alina Popa Cherecheanu; Catalina Ionescu; Dana Dascalescu; Vasile Potop; Marian Burcea

doi:10.1155/2019/4960852

Update on Myopia Risk Factors and Microenvironmental Changes

J Ophthalmol. 2019 Oct 31:2019:4960852. doi: 10.1155/2019/4960852. eCollection 2019.

Authors

Valeria Coviltir^{1

2}, Miruna Burcel³, Alina Popa Cherecheanu^{1

4}, Catalina Ionescu⁵, Dana Dascalescu³, Vasile Potop^{1

2

3}, Marian Burcea^{1

2}

Affiliations

¹ Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, Bd. Eroii Sanitari 8, Bucharest, Romania.
² Clinical Hospital of Ophthalmologic Emergencies (S.C.U.O), Alexandru Lahovari Square 1, Bucharest, Romania.
³ Oftaclinic Clinic, Bd. Marasesti 2B, Bucharest, Romania.
⁴ Department of Ophthalmology, University Emergency Hospital, Splaiul Independenței 169, Bucharest, Romania.
⁵ CMDTAMP Clinic, Bucharest, Romania.

Abstract

The focus of this update is to emphasize the recent advances in the pathogenesis and various molecular key approaches associated with myopia in order to reveal new potential therapeutic targets. We review the current evidence for its complex genetics and evaluate the known or candidate genes and loci. In addition, we discuss recent investigations regarding the role of environmental factors. This paper also covers current research aimed at elucidating the signaling pathways involved in the pathogenesis of myopia.

Publication types

Review