Associations of urinary di-(2-ethylhexyl) phthalate metabolites with the residential characteristics of pregnant women

Abstract

Epidemiological evidence on the associations between urinary di-(2-ethylhexyl) phthalate (DEHP) metabolites and residential characteristics is limited. Therefore, we investigated the associations of urinary DEHP metabolites with the residential characteristics of pregnant women. We collected completed questionnaires and maternal spot urine samples from 616 random pregnant women in Shengjing Hospital of China Medical University in Shenyang. Urinary DEHP metabolites concentrations, including mono-(2-ethylhexyl) phthalate (MEHP) and mono (2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), were measured and analyzed by Gas Chromatography-Mass Spectrometry (GC-MS). Multivariable linear regression models were performed to obtain regression estimates (β) and 95% confidence intervals (CIs) after adjustment for sociodemographic characteristics. In all participants, the geometric mean of MEHP and MEHHP concentrations were 4.25 ± 4.34 and 5.72 ± 2.65 μg/L, respectively. In multivariable analyses after adjusting for sociodemographic characteristics, distance from residence to motor vehicle traffic (≥150 m versus <20 m) was negatively associated with MEHP (β = -0.241, 95% CI: -0.448, -0.033) and MEHHP (β = -0.279, 95% CI: -0.418, -0.140) concentrations. Compared with the one that had not recently been renovated, a renovated home was associated with higher MEHP (β = 0.194, 95% CI: 0.064, 0.324) and MEHHP (β = 0.111, 95% CI: 0.024, 0.197) concentrations. Air freshener use was associated with higher MEHP (β = 0.322, 95% CI: 0.007, 0.636) concentrations. Moldy walls were positively associated with MEHP (β = 0.299, 95% CI: 0.115, 0.482) and MEHHP (β = 0.172, 95% CI: 0.050, 0.294) concentrations. In contrast, humidifier use was associated with a lower MEHP concentration (β = -0.167, 95% CI: -0.302, -0.032). Residential characteristics were probably associated with the DEHP exposure of pregnant women in Shenyang. Living near the motor vehicle traffic, residential renovation, air freshener use, and moldy walls are likely risk factors for increased DEHP exposure, whereas using household humidifier could be considered a protective measure to reduce DEHP exposure.

Keywords: DEHP exposure; Humidifier; Pregnant women; Residential characteristics.